The origins of the clandestine Weapon X Program date back to 1945 when a civilian advisor to the American military named Thorton investigated a liberated concentration camp and discovered the hidden laboratory of the enigmatic geneticist Mister Sinister. Using Sinister’s research as the basis for his own work, Thorton, also known simply as the Professor, formed the Weapon plus program at the behest of the U.S. government. Absorbing the resources of earlier government projects such as Operation: Rebirth, which was retroactively designated Weapon I, Weapon Plus was dedicated to the creation of super-soldiers. Over the next decade and a half, the Program went through various stages of development. The Weapon II and III Programs used animals as test subjects, while Weapons IV, V, and VI experimented upon various ethnic minorities. Beginning with Weapon VII, superhuman mutants became the preferred test subjects, a trend which continued from Weapon VIII through Weapon IX. The Professor remained active as a scientist throughout these incarnations of Weapon Plus, only to be repeatedly passed up for promotion.
By the 1960s, the Program had advanced to Weapon X and operated under the auspices of the Central Intelligence Agency. Several mutant operatives were organized as the covert operations unit Team X, including Wolverine, Sabretooth, Maverick, Wraith, Mastodon, and Silver Fox. The members of Team X were implanted with false memories by Psi-Borg, a telepathic ally of the Program, with the ultimate intent of suppressing their true memories and awareness of their abilities to become sleeper agents. A separate branch of the program, the Shiva Scenario, was designed to dispatch heavily armored robots to kill any operatives that went rogue. Team X members also received age suppression and healing factor treatments based on Wolverine’s own mutant nature. By the early 1970s, Team X had been disbanded, with only Wraith and Maverick remaining in government service. The Weapon X Program continued operations under the cover of a division of the U.S. Department of Agriculture.
Over a decade later, the U.S. and Canadian governments were jointly administrating the Weapon X Program, with its Canadian branch in turn jointly operated by Canada’s Department K and Department H. In this incarnation, Weapon X oversaw the enhancement of various Canadian government operatives, both human and mutant. One such operative was Wade Wilson, who received an artificial healing factor based on the one possessed by Wolverine. The Program was less than successful as most of the participants suffered from various physical or mental breakdowns and were sent to a special Hospice, where, unknown to the Canadian government, scientist Doctor Killebrew conducted inhumane experiments in his Workshop with his assistant, Ajax. Killebrew’s activities were disrupted when Wilson, calling himself Deadpool, led a massive breakout, and Canada eventually shut down its Weapon X branch.